MACS/WIHS Combined Cohort Study

MWCCS COVID-19 Communication

Interim Guidance for COVID-19 and Persons with HIV

As of January 1, 2019, the MACS and WIHS cohorts combined to form the MACS/WIHS Combined Cohort Study (MWCCS). Please use this website for all historical MACS and WIHS projects, along with new CCS projects.

The Multicenter AIDS Cohort Study (MACS) / Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS) is a collaborative research effort that aims to understand and reduce the impact of chronic health conditions—including heart, lung, blood, and sleep (HLBS) disorders—that affect people living with HIV.

For decades, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), has supported the separate MACS and WIHS cohort studies. MACS was a study of gay and bisexual men, while WIHS was a study of women who had other risk factors for HIV.

In 2019, the NHLBI became the primary steward of the new MACS/WIHS CCS. For this effort, the NHLBI is working in close collaboration with the NIH Office of AIDS Research (OAR) as well as several co-funding institutes across the NIH.

The Changing Science of HIV Epidemiology in the United States. Gypsyamber D’Souza, Elizabeth T. Golub, Stephen J. Gange. American Journal of Epidemiology, Volume 188, Issue 12, December 2019, Pages 2061-2068.