MACS/WIHS Combined Cohort Study

As of January 1, 2019, the MACS and WIHS cohorts have combined to form the MACS/WIHS Combined Cohort Study (CCS). Please use this website for all historic MACS and WIHS projects, along with new CCS projects.

The Multicenter AIDS Cohort Study (MACS) / Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CCS) is a collaborative research effort that aims to understand and reduce the impact of chronic health conditions—including heart, lung, blood, and sleep (HLBS) disorders—that affect people living with HIV.

For decades, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), has supported the separate MACS and WIHS cohort studies. MACS was a study of gay and bisexual men, while WIHS was a study of women who had other risk factors for HIV.

In 2019, the NHLBI became the primary steward of the new MACS/WIHS-CCS. For this effort, the NHLBI is working in close collaboration with the NIH Office of AIDS Research (OAR) as well as several co-funding institutes across the NIH.